Jacob's Syndrome By: Ginger and morgan
What is this disease called?
- Jacob Syndrome
- XYY Syndrome
- XYY Karyotype
- YY Syndrome
The causes and inheritance:
Jacob's Syndrome is a random mix up or mutation during creation of genetic code. Most cases are not inherited; having Jacob’s syndrome does not make your children more likely to have it. The mutation can occur at any point during meiosis of sperm cells-- some cells can have the mutation while others don’t. The mutation is a form of nondisjunction.
Phenotypic Effects:
- Taller than average
- Weaker muscle tone
- Severe cystic acne during adolescence
- Fairly normal intelligence: on average IQ is 10 to 15 points lower than siblings
- Mild delays in reaching developmental milestones
- Speech delays and language problems are common
- Reading difficulties are common due to an increased incidence of dyslexia
Social Issues:
- Increased risk for behavioral issues and learning disabilities
- Thought that they were overly aggressive and lacked empathy but recent studies have proved that wrong
- Generally they lead full, healthy lives