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INTRODUCTION TO SKIN MICROBIOME TESTING Is your product microbiome friendly?

What is the skin microbiota and what is the skin microbiome?

MICROBIOTA

The skin microbiota is the term usually used to refer to microorganisms - bacteria, viruses, and fungi - living on human skin.

MICROBIOME

The skin microbiome is the collection of genomes from all the microorganisms found in the skin.

Why the skin microbiome is important?

In recent years, researchers have uncovered evidence of communication between bacteria, skin cells, and immune cells. These interactions help to reinforce and repair the skin barrier while supporting the skin defences against infections and inflammation. (1)

What is the skin microbiome composition and how it is influenced by skin conditions?

Most (>90%) of bacteria of the human skin microbiome are classified into four types: Actinobacteria (52%), Firmicutes (24%), Proteobacteria (16%), and Bacteroidetes (6%). (2)

The composition of microbial communities was found to be primarily dependent on the physiology of the skin site, with changes in the relative abundance of bacterial taxa associated with moist, dry and sebaceous microenvironments. Sebaceous sites were dominated by lipophilic Propionibacterium species, whereas bacteria that thrive in humid environments, such as Staphylococcus and Corynebacterium species, were preferentially abundant in moist areas, including the bends of the elbows and the feet. (3)

Is the skin microbiome influenced by ethnicity?

Among the genetic factors shaping the skin microbiome, ethnicity appears to be secondary, but not insignificant. (2)

A study by Li et al. revealed that the skin microbiome composition of East Asian people is specific. (4)

The number of Cutibacterium on the scalp and armpits of males in Africa and Latin America is lower than in other ethnicities (Caucasian, African-American, East Asian, and South Asian). The microbiomes of the arms of African-American men and the armpits of East Asians were significantly different compared to other groups. (5)

Despite some similarities, the Chinese skin microbiome differed from other populations. (6)

How skin microbiome is tested?

COMPLIFE CLINICIANS & RESEARCHERS HAVE WORKED HARD OVER THE LAST YEAR TO DEVELOP THE

SKIN MICROBIOME PROTOCOL

FROM SAMPLING TO ANALYSIS WE HAVE DEVELOPED A RELIABLE METHOD BASED ON 16S rRNA SEQUENCING.

ASK OUR SCIENTISTS FOR MORE INFORMATION ON HOW TO EVALUATE YOUR MICROBIOME FRIENDLY PRODUCT.

vincenzo.nobile@complifegroup.com

(1) Michael Eisenstein. The skin microbiome. Nature | Vol 588 | 17 December 2020 | S209 2 - (2) Skowron K, Bauza-Kaszewska J, Kraszewska Z, Wiktorczyk-Kapischke N, Grudlewska-Buda K, Kwiecińska-Piróg J, Wałecka-Zacharska E, Radtke L, Gospodarek-Komkowska E. Human Skin Microbiome: Impact of Intrinsic and Extrinsic Factors on Skin Microbiota. Microorganisms. 2021 Mar 5;9(3):543. doi: 10.3390/microorganisms9030543. PMID: 33808031; PMCID: PMC7998121 - (3) Byrd AL, Belkaid Y, Segre JA. The human skin microbiome. Nat Rev Microbiol. 2018 Mar;16(3):143-155. doi: 10.1038/nrmicro.2017.157. Epub 2018 Jan 15. PMID: 29332945 - (4) Li, M.; Budding, A.E.; van der Lugt-Degen, M.; Du-Thumm, L.; Vandeven, M.; Fan, A. The influence of age, gender and race/ethnicity on the composition of the human axillary microbiome. Int. J. Cosmet. Sci. 2019, 41, 371–377 - (5) Perez Perez, G.I.; Gao, Z.; Jourdain, R.; Ramirez, J.; Gany, F.; Clavaud, C.; Demaude, J.; Breton, L.; Blaser, M.J. Body Site Is a More Determinant Factor than Human Population Diversity in the Healthy Skin Microbiome. PLoS ONE 2016, 11, e0151990 - (6) Leung, M.H.;Wilkins, D.; Lee, P.K. Insights into the pan-microbiome: Skin microbial communities of Chinese individuals differ from other racial groups. Sci. Rep. 2015, 5, 11845.