In 1898 Curie discovered a mineral called pitchblende. She noticed it contained uranium ore in it. There was a large radioactive level in it, more than in normal uranium. It was only presented in small quantities and it was very radioactive. Since it had never been discovered before Curie believed she had discovered a new element. How ever many other scientist doubted her discoveries.
Pitchblende was expensive and valuable due to the radium it contains. In order to isolate the radium they needed a lot of it. After a long difficult journey they were finally able to do that in 1902.
Sadly and ironically Curie died of pernicious anemia that she got from exposure to radiation from her life work. Curie was an astonishing woman that had many great accomplishments and she will forever be remembered for her amazing work.
http://www.nobelprize.org/nobel_prizes/physics/laureates/1903/marie-curie-bio.html
https://www.mariecurie.org.uk/who/our-history/marie-curie-the-scientist
https://www.nobelprize.org/nobel_prizes/themes/physics/curie/