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7T Translational Alliance in North America 7T TANA

Mission

Composed of 30+ sites across the US and Canada (map below)

Our mission is to translate the powerful imaging capabilities of 7 Tesla magnetic resonance imaging (MRI) to real-life benefits for patients, healthcare providers, and researchers in North America and worldwide.

The 7T TANA will facilitate the standardization of imaging protocols, sharing of data and expertise, and the formation of multi-site trials for the discovery and evaluation of clinical values using 7T MRI.

Sponsors:

News

A Kick-off Meeting will be held on July 31, 2023, in Los Angeles, CA at the USC Health Sciences Campus Conference Center (Hyatt house).

About 7T MRI

7T MRI is a non-invasive imaging device that uses ultra-high magnetic field of 7 Tesla to scan the human body. 7T MRI does not expose patients to ionizing radiation (like X-ray), and some 7T MRI systems have been cleared by the FDA for clinical use.

A crucial benefit of 7T MRI is the high signal-to-noise ratio (SNR) and high sensitivity that allow doctors and researchers to see intricate anatomical details - often with sub-millimeter resolution - and to measure various functions of the human body. 7T MRI makes many new features visible to doctors that would otherwise not be visible at a standard field strength of 1.5 and 3T.

To date, clinical benefits of 7T MRI have been shown in a range of neurologic disorders including epilepsy, multiple sclerosis (MS), planning for deep brain stimulation (DBS), cerebral small vessel disease (cSVD), as well as musculoskeletal (MSK) imaging. See For Providers below for more details.

For Patients

7T MRI is a non-invasive magnetic resonance imaging technique, which uses a strong magnetic field of 7 Tesla to image human anatomies. Compared to clinical MRI at 1.5 and 3T, 7T MRI enables the imaging of the human body and tissues with very high resolution (sub-millimeter). Many imaging technologies have been developed and optimized for 7T MRI. Some imaging protocols can generate the paths of nerves, while others can detect functional brain maps. Some images can depict angiograms for vascular imaging, iron deposition, and metabolic activities can also be quantified. 7T MRI has been shown to detect subtle abnormalities related to several neurological diseases (epilepsy, multiple sclerosis, cerebral small vessel disease, and more), and can guide the placement of deep brain stimulation.

Is it safe? The radio frequency of a 7T MRI system (about 300 MHz) is much lower than that of Wi-Fi and cell phones. It does not cause any ionizing radiation (like X-ray). The FDA has cleared some 7T MRI systems for clinical use. However, since it is a very powerful magnet, patients and volunteers with implants in their bodies may not be eligible for scans. The main risk of 7T MRI is the heating due to radio frequency (RF) pulses which need to be closely monitored. The subject may feel dizzy when moving in and out of the magnet, and the space is more confined compared to standard clinical MRI at 1.5 and 3T. Although there is no evidence of harm, people who are or may be pregnant should not undergo 7T MRI. Trained personnel should perform the final risk evaluation of a subject at the imaging site. Also, people weighing less than 30kg/66 lbs should not have 7T scans.

The frequency of having a 7T MRI depends on you and your healthcare provider. 7T MRI is not a treatment - it is a very powerful diagnostic tool. You can undergo 7T MRI as often as your provider requests and you feel comfortable. Since there is no ionizing radiation hazard, there is no limitation to the number of visits or duration of each visit. However, if you are or may be pregnant, you should not undergo 7T MRI.

Is 7T MRI covered by insurance? Please consult with your healthcare provider and insurance company regarding insurance coverage. Some but not all 7T MRI exams are covered by insurance.

Where to get a 7T MRI? To find a 7T MRI location, you may use our search tool here.

3T left, 7T right

For Providers

To date, clinical benefits of 7T MRI have been shown in a range of neurologic disorders including epilepsy, multiple sclerosis (MS), planning for deep brain stimulation (DBS), cerebral small vessel disease (cSVD), as well as musculoskeletal (MSK) imaging.

New clinical benefits of 7T MRI are continuously being discovered. Sample 7T MRI images from literature are shown below.

Epilepsy

Epilepsy: Identifying very small brain lesions on MRI is very important in epilepsy. Conventional MRI field strengths (1.5T and 3T) can only reveal 60%-85% of these lesions. The 7T Epilepsy Task Force recommended the use of 7T MRI in clinical practice. Here is an example of how 7T can detect subtle abnormalities in the brain. The red crosshairs/arrows pinpoint the location of an area of focal cortical dysplasia (FCD), which was detected by visual analysis of 7T images. The vascular changes associated with the FCD can be well appreciated on the T2*-weighted GRE images in panel C (arrows). Source: 7T Epilepsy Task Force Consensus Recommendations on the Use of 7T MRI in Clinical Practice, Neurology 2021.

Multiple Sclerosis (MS)

Multiple Sclerosis (MS): 7T MRI offers increased signal-to-noise ratio (SNR) and enhanced susceptibility effects, improves conspicuity of MS pathological hallmarks including cortical demyelination and the central vein sign. Observations from postmortem studies suggest that UHF imaging enhances sensitivity for cortical lesion detection up to approximately 30% to 40% (see sample images).
Multiple Sclerosis (MS): 7T MRI offers superior conspicuity of veins due to enhanced contrast-to-noise ratio for detecting central vein signs (see sample images). Source: New Prospects for Ultra-High-Field Magnetic Resonance Imaging in Multiple Sclerosis Investigative Radiology 2021.

DBS planning

DBS planning: Deep brain stimulation (DBS) is essential in treating advanced Parkinson disease (PD). 7T MRI enables better visualization of targets for DBS in PD. 7T MRI provides higher image contrast and resolution for brain tissues especially subcortical nuclei due to strong susceptibility contrast (see sample images of subthalamic nucleus (STN) and globus pallidus internus (Gpi)). Other conditions that may benefit from 7T MRI for DBS planning include tremor, dystonia, chronic pain, obsessive-compulsive disorder, and depression. Source: Direct visualization of deep brain stimulation targets in Parkinson's disease with the use of 7-tesla magnetic resonance imaging J Neurosurg 2010.

Cerebral small vessel disease (cSVD)

Cerebral small vessel disease (cSVD): Ultra-high resolution MRA imaging using 7T MRI can be employed to noninvasively visualize the lenticulostriate arteries (LSA) that supply the basal ganglia and internal capsule. One study reported the LSA branch number and radii are reduced in persons with subcortical vascular dementia (SVaD). Source: Measurements of lenticulostriate arteries using 7T MRI: new imaging markers for subcortical vascular dementia Journal of the Neurological Sciences. 2012
Cerebral small vessel disease (cSVD): 7T MRA study detected a decrease in the number of LSA branches, and an increase in the proportion of discontinuous LSAs in patients with genetic cSVD (CADASIL) compared with healthy controls (see sample images). 7T MRI is also able to visualize lacuna infarcts (C), white matter hyperintensity (D), and cerebral microbleeds (E) in CADASIL patients with great detail and conspicuity. Source: Lenticulostriate Arteries and Basal Ganglia Changes in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy, a High-Field MRI Study Frontier in Neurology 2019.

Musculoskeletal MRI (MSK)

Musculoskeletal MRI (MSK): 7T MRI provides higher spatiotemporal and spectral resolution compared to 1.5 or 3T MRI (see sample images showing improved spatial and contrast resolution for cartilage visualization at 7T). Better morphologic, biochemical, and functional details of musculoskeletal tissues can be observed using 7T MRI which improves diagnostic accuracy, in particular articular cartilage. Source: Musculoskeletal MRI at 7 T: do we need more or is it more than enough? European Radiology Experimental 2020.

For Researchers

The 7T TANA will facilitate the standardization of imaging protocols, sharing of data and expertise, and the formation of multi-site trials for the discovery and evaluation of clinical values using 7T MRI.

Galleries

High Resolution T2w MRI of Hippocampus

7T T2 TSE, 0.1x0.1x2.0mm3
3T T2 TSE, 0.4x0.4x2.0mm3
Left: 7T T2 TSE, 0.1x0.1x2.0mm3. Right: 3T T2 TSE, 0.4x0.4x2.0mm3

High Resolution T2w MRI of Perivascular Space (PVS)

Susceptibility weighted imaging (SWI)

Left: 7T SWI minIP, 0.2x0.2x1.5mm3, Right: 3T SWI minIP, 0.9x0.9x1.2mm3

Time-of-Flight MR Angiography (TOF MRA)

Left: 7T MRA TOF. 0.3mm isotropic, Right: MRA TOF, 0.3mm isotropic

Diffusion MRI Tractography

Tractography and Cortical Diffusion MRI. 7T enables cortical fiber orientation mapping.
Multi-Shell HARDI Diffusion MRI, Left: 7T diffusion b=0, 1000, 2000, 1.25mm isotropic, Right: 3T diffusion b=0, 1500, 3000, 1.5mm isotropic

Arterial spin labeling (ASL) perfusion MRI

7T 3D pCASL CBF 2x2x4mm3
3T 3D pCASL CBF 2x2x4mm3
Left: 7T 3D pCASL CBF 2x2x4mm3, Right: 3T 3D pCASL CBF 2x2x4mm3

Internal auditory canal imaging

Left internal auditory canal at 7T: T2space acquisition at 0.63mm3

Proton MR Spectroscopy (MRS)

Fast spectroscopic imaging (TE40ms, TA 4.5min)

For More Information

Contact us at: 7Talliance@gmail.com