森田・小俣 研究室 医学，薬学，生物学に機械工学の見地からアプローチする

実験力学

「百聞は一見に如かず．」　物理現象の理解には，その現象の可視化が大きな役割を果たす．実験力学は，その可視化を実現する先端的な計測技術を開発し，その現象の解明に挑む学問である．本研究室では，マイクロ・ナノメートル領域の応力・ひずみを可視化し，細部に宿る力学現象の解明に取り組んでいる．

【研究テーマの例】

• デジタル画像相関法（DIC）の開発・応用
• デジタルボリューム相関法（DVC）の開発・応用
• マイクロレオロジー測定技術の開発・応用
• 光干渉計測技術の開発・応用

ソフトメカニクス

細胞や臓器など人体のほとんどは“やわらい”材料「ソフトマター」で構成されている．本研究室では，“やわらい”の物理的・機械的な特徴を応用して，新機能をもつ機械材料・構造部材の設計・開発を行っている．そしてこの研究を通して，再生医療や医学教育，ロボット工学など様々な分野にチャレンジしている．

【研究テーマの例】

• 眼科手術シミュレータの眼球モデルの開発
• ソフトアクチュエータの開発
• ソフトマテリアルを用いたセンサの開発

PRINCIPAL INVESTIGATOR

教授　森田 康之，博士(工学)

Co-PRINCIPAL INVESTIGATOR

助教　小俣 誠二，博士(工学)

D1

• 熊　宇霖（寺田寅彦フェローシップ）

M2

• 高井　研太朗
• 野下　渉
• 福田　圭佑
• 福本　圭志
• 前田　圭佑
• 宮原　啓輔

M1

• 高木　裕作
• 竹嵜　海翔
• 田中　昴斗
• 辻　大河
• 豊永　雄大
• 西迫　武人
• 東　大地
• 郜　昂
• 蔣　錕

B4

• 大城　彰斗
• 小原　裕汰
• 金丸　航大
• 畑　勇輝
• 森　龍之介

研究生

• 瀋　欣鈺

2022

• Y. Morita, K. Kobayashi, Y. Toku, Y. Kimura, Q. Luo, G. Song, Y. Ju, “Nanocarriers for drug-delivery systems using a ureido-derivatized polymer gatekeeper for temperature-controlled spatiotemporal on–off drug release,” Biomaterials Advances, Vol.139, 213026, 2022.
• 森田康之, 巨陽, “tLyP-1ペプチドを用いた標的指向型DDSナノキャリアの開発,” 中分子創薬に向けたDDS開発の新展開(杉林堅次監修), 第21章, シーエムシー出版, 2022.
• Y. Morita, “A technique for measuring the 3D deformation of a multiphase structure to elucidate the mechanism of tumor invasion,” Multidisciplinary Computational Anatomy, ed by M. Hashizume (ISBN: 978-981-16-4324-8), pp.139-143, Springer, 2022.
• Y. Taniguchi, H. Sugiura, T. Yamanaka, S. Watanabe, S. Omata, K. Harada, M. Mitsuishi, T. Shiraya, K. Sugimoto, T. Ueta, K. Totsuka, F. Araki, M. Takao, M. Aihara, F. Arai, “A force measurement platform for a vitreoretinal surgical simulator using an artificial eye module integrated with a quartz crystal resonator,” Microsystems & Nanoengineering, Vol.8, Article No.74, 2022.
• T. Yamanaka, T. Niino, S. Omata, K. Harada, M. Mitsuishi, K. Sugimoto, T. Ueta, K. Totsuka, T. Shiraya, F. Araki, M. Takao, M. Aihara, F. Arai, “Bionic eye system mimicking microfluidic structure and intraocular pressure for glaucoma surgery training,” PLoS ONE, in press, 2022.

2021

• 森田康之, “デジタル画像相関法　事例2　DVC法の適用事例,” 機械設計, 特集“ひずみ・応力測定の基礎と評価法,” Vol.65, No.12, pp.34-37, 2021.
• 森田康之, “全視野変形計測のためのデジタル画像相関法の基礎と応用,” 整形・災害外科, Vol.64, No.5, pp.667-673, 2021.
• B. Tong, T. Hirabayashi, Y. Toku, Y. Morita, Y. Ju, “Non-contact local conductivity measurement of metallic nanowires based on semi-near-field reflection of microwave atomic force microscopy,” Applied Physics Express, Vol.118, 193103, 2021.
• Y. Toku, Y. Togawa, Y. Morita, Y. Ju, “Preferential growth of specific crystal planes based on the dimension control of single crystal SnO2 nanobelts,” Materials Letters, Vol.285, 129121, 2021.

2020

• 小俣誠二, 栗田史哉, 酒井友里江, 巨陽, 森田康之, “伸縮可能な基材の溝幅が幹細胞の腱細胞分化誘導へ与える影響,” 実験力学, Vol.20, No.3, pp.173-178, 2020.

2019

• Y. Morita, T. Sato, K. Higashiura, Y. Hirano, F. Matsubara, K. Oshima, K. Niwa, Y. Toku, G. Song, Q. Luo, Y. Ju, “The optimal mechanical condition in stem cell-to-tenocyte differentiation determined with the homogeneous strain distributions and the cellular orientation control,” Biology Open, Vol.8, Issue5, bio039164, 2019.
• B. Tong, M. Zhao, Y. Toku, Y. Morita, Y. Ju, “Local permittivity measurement of dielectric materials based on the noncontact force curve of microwave atomic force microscopy,” Review of Scientific Instruments, Vol.90, 033706, 2019.
• Y. Morita, R. Sakurai, T. Wakimoto, K. Kobayashi, B. Xu, Y. Toku, G. Song, Q. Luo, Y. Ju, “tLyP-1-conjuagted core-shell nanoparticles, Fe3O4@mSiO2, for tumor-targeted drug delivery,” Applied Surface Science, Vol.474, pp.17-24, 2019.
• Y. Toku, K. Ichioka, Y. Morita, Y. Ju, “A 64-pin nanowire surface fastener like a ball grid array applied for room-temperature electrical bonding,” Scientific Reports, Vol.9, No.1, 1095, 2019.
• M. Gallab, S. Omata, K. Harada, M. Mitsuishi, K. Sugimoto, T. Ueta K. Totsuka, F. Araki, M. Takao, M. Aihara, F. Arai, "Development of a spherical model with a 3D microchannel: an application to glaucoma surgery," Micromachines, Vol.10, No.5, 297, 2019.

2018

• Y. Yin, H. Chen, Y. Morita, Y. Toku, Y. Ju, “Effect of electropulsing treatment on the fatigue crack growth behavior of copper," Materials, Vol.11. No.11, 2168, 2018.
• K. Yan, Y. Toku, Y. Morita, Y. Ju, “Fabrication of multiwall carbon nanotube sheet based hydrogen sensor on a stacking multi-layer structure,” Nanotechnology, Vol.29, No.37, 375503, 2018.
• Y. Morita, F. Matsubara, Y. Toku, Y. Ju, “Use of a tendon/ligament cell sheet with mesenchymal stem cells and cyclic stretch stimulus for tendon/ligament tissue restoration,” Journal of Mechanical Engineering, Vol. SI5, No.3, pp.1-11, 2018.
• Y. Toku, K. Uchida, Y. Morita, Y. Ju, “Nanowire surface fastener fabrication on flexible substrate,” Nanotechnology, Vol.29, No.30, 305702, 2018.
• G. Song, B. Zhang, Q. Luo, B. Deng, Y. Morita, Y. Ju, “Construction of tendon replacement tissue based on collagen sponge and mesenchymal stem cells by coupled mechano-chemical induction and its evaluation in tendon repair abilities,” Acta Biomaterialia, Vol.74, pp.247-259, 2018.
• Y. Xie, Y. Ju, Y. Toku, Y. Morita, “Synthesis of single-crystalline Fe2O3 nanowire array based on stress-induced atomic diffusion used for solar water splitting,” Royal Society Open Science, Vol.5, No.3, 172126, 2018.
• L. Liu, Q. Luo, J. Sun, Y. Ju, Y. Morita, Y. Shi, W. Liu, G. Song, “Chromatin organization regulated by EZH2-mediated H3K27me3 is required for OPN-induced migration of bone marrow-derived mesenchymal stem cells,” The International Journal of Biochemistry & Cell Biology, Vol. 96, pp.29-39, 2018.
• Y. Morita, T. Yamashita, Y. Toku, Y. Ju, “Optimization of differentiation time of mesenchymal-stem-cell to tenocyte under a cyclic stretching with a microgrooved culture membrane and selected measurement cells,” Acta of Bioengineering and Biomechanics, Vol. 20, No. 1, pp.3-10, 2018.
• Q. Chen, Q. Liang, W. Zhuang, J. Zhou, B. Zhang, P. Xu, Y. Ju, Y. Morita, Q. Luo, G. Song, “Tenocyte proliferation and migration promoted by rat bone marrow mesenchymal stem cell-derived conditioned medium,” Biotechnology Letters, Vol.40, No.1, pp.215-224, 2018.
• S. Omata, Y. Someya, S. Adachi, T. Masuda, K. Harada, M. Mitsuishi, K. Totsuka, F. Araki, M. Takao, M. Aihara, F. Arai, "A surgical simulator for peeling the inner limiting membrane during wet conditions," PLoS ONE, Vol.13, No.5, e0196131, 2018.
• S. Sasaki, S. Omata, T. Murakami, N. Nagasawa, M. Taguchi, A. Suzuki, "Effect of gamma ray irradiation on friction property of hybrid PVA gel," Gels, Vol.4, No.2, 30, 2018.
• M. Gallab, K. Tomita, S. Omata, F. Arai, "Fabrication of 3D capillary vessel models having circulatory connection ports," Micromachines, Vol.9, No.3, 101, 2018.